Mechanisms of lymphatic metastasis
Identifieur interne : 002841 ( Main/Exploration ); précédent : 002840; suivant : 002842Mechanisms of lymphatic metastasis
Auteurs : Sinem Karaman ; Michael DetmarSource :
- The Journal of Clinical Investigation [ 0021-9738 ] ; 2014.
Abstract
Malignant tumors release growth factors such as VEGF-C to induce lymphatic vessel expansion (lymphangiogenesis) in primary tumors and in draining sentinel LNs, thereby promoting LN metastasis. Surprising recent evidence suggests that lymphatic vessels do not merely represent passive channels for tumor spread, but that they may actively promote tumor cell recruitment to LNs, cancer stem cell survival, and immune modulation. New imaging approaches allow the sensitive visualization of the earliest LN metastases and the quantitative, noninvasive measurement of the function of tumor-draining lymphatic vessels, with potential applications in the development of biomarkers for prognosis and measurement of therapeutic response.
Url:
DOI: 10.1172/JCI71606
PubMed: 24590277
PubMed Central: 3938272
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 004848
- to stream Pmc, to step Curation: 004847
- to stream Pmc, to step Checkpoint: 001A08
- to stream Ncbi, to step Merge: 006383
- to stream Ncbi, to step Curation: 006383
- to stream Ncbi, to step Checkpoint: 006383
- to stream Main, to step Merge: 002845
- to stream Main, to step Curation: 002841
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Mechanisms of lymphatic metastasis</title>
<author><name sortKey="Karaman, Sinem" sort="Karaman, Sinem" uniqKey="Karaman S" first="Sinem" last="Karaman">Sinem Karaman</name>
</author>
<author><name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">24590277</idno>
<idno type="pmc">3938272</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938272</idno>
<idno type="RBID">PMC:3938272</idno>
<idno type="doi">10.1172/JCI71606</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">004848</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004848</idno>
<idno type="wicri:Area/Pmc/Curation">004847</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">004847</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001A08</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001A08</idno>
<idno type="wicri:Area/Ncbi/Merge">006383</idno>
<idno type="wicri:Area/Ncbi/Curation">006383</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">006383</idno>
<idno type="wicri:doubleKey">0021-9738:2014:Karaman S:mechanisms:of:lymphatic</idno>
<idno type="wicri:Area/Main/Merge">002845</idno>
<idno type="wicri:Area/Main/Curation">002841</idno>
<idno type="wicri:Area/Main/Exploration">002841</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Mechanisms of lymphatic metastasis</title>
<author><name sortKey="Karaman, Sinem" sort="Karaman, Sinem" uniqKey="Karaman S" first="Sinem" last="Karaman">Sinem Karaman</name>
</author>
<author><name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name>
</author>
</analytic>
<series><title level="j">The Journal of Clinical Investigation</title>
<idno type="ISSN">0021-9738</idno>
<idno type="eISSN">1558-8238</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Malignant tumors release growth factors such as VEGF-C to induce lymphatic vessel expansion (lymphangiogenesis) in primary tumors and in draining sentinel LNs, thereby promoting LN metastasis. Surprising recent evidence suggests that lymphatic vessels do not merely represent passive channels for tumor spread, but that they may actively promote tumor cell recruitment to LNs, cancer stem cell survival, and immune modulation. New imaging approaches allow the sensitive visualization of the earliest LN metastases and the quantitative, noninvasive measurement of the function of tumor-draining lymphatic vessels, with potential applications in the development of biomarkers for prognosis and measurement of therapeutic response.</p>
</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name>
<name sortKey="Karaman, Sinem" sort="Karaman, Sinem" uniqKey="Karaman S" first="Sinem" last="Karaman">Sinem Karaman</name>
</noCountry>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002841 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002841 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:3938272 |texte= Mechanisms of lymphatic metastasis }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:24590277" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
This area was generated with Dilib version V0.6.31. |